MULTI-BIOINFORMATICS REVEALED POTENTIAL BIOMARKERS AND REPURPOSED DRUGS FOR GASTRIC ADENOCARCINOMA-RELATED GASTRIC INTESTINAL METAPLASIA

Multi-bioinformatics revealed potential biomarkers and repurposed drugs for gastric adenocarcinoma-related gastric intestinal metaplasia

Abstract Biomarkers associated with the progression from gastric intestinal metaplasia (GIM) to gastric adenocarcinoma (GA), i.e., GA-related GIM, could provide valuable insights into identifying patients with increased risk for GA.The aim of this study was to utilize multi-bioinformatics to reveal potential biomarkers for the GA-related GIM and pr

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The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.

The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure.Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and read more ovary developme

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Hospital-based interventions: a systematic review of staff-reported barriers and facilitators to implementation processes

Abstract Background Translation moen finney of evidence-based interventions into hospital systems can provide immediate and substantial benefits to patient care and outcomes, but successful implementation is often not achieved.Existing literature describes a range of barriers and facilitators to the implementation process.This systematic review ide

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